Sigrid Langhans, PhD

Tryptophan Kynurenine Pathway-Based Imaging Agents for Brain Disorders and Oncology—From Bench to Bedside; Biomolecules; (2025).

YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders; Frontiers in Cell and Developmental Biology; (2025).

Radiotracers for Molecular Imaging of Angiotensin-Converting Enzyme 2; International Journal of Molecular Sciences; (2024).

PET Imaging of Neurofibromatosis Type 1 with a Fluorine-18 Labeled Tryptophan Radiotracer; Pharmaceuticals; (2024).

3D Hydrogel Cultures for High-Throughput Drug Discovery; Methods in molecular biology (Clifton, N.J.); (2023).

Abusive Head Trauma Animal Models: Focus on Biomarkers; International Journal of Molecular Sciences; (2023).

Advanced Neuroimaging Approaches to Pediatric Brain Tumors; Cancers; (2022).

In Vivo and Ex Vivo Pediatric Brain Tumor Models: An Overview; Frontiers in Oncology; (2021).

Radiosynthesis of 1-(2-[18f]fluoroethyl)-l-tryptophan using a one-pot, two-step protocol; Journal of Visualized Experiments; (2021).

Unravelling neuroinflammation in abusive head trauma with radiotracer imaging; Pediatric Radiology; (2021).

Using 3D in vitro cell culture models in anti-cancer drug discovery; Expert Opinion on Drug Discovery; (2021).

PET imaging of medulloblastoma with an ¹⁸F-labeled tryptophan analogue in a transgenic mouse model; Scientific Reports; (2020).

Implementation of a High-Throughput Pilot Screen in Peptide Hydrogel-Based Three-Dimensional Cell Cultures; SLAS Discovery; (2019).

A Functional Interaction Between Na,K-ATPase β₂-Subunit/AMOG and NF2/Merlin Regulates Growth Factor Signaling in Cerebellar Granule Cells; Molecular Neurobiology; (2019).

Moving myeloid leukemia drug discovery into the third dimension; Frontiers in Pediatrics; (2019).

RADI-17. EVALUATION OF A NOVEL F-LABELED TRYPTOPHAN TRACER FOR PET IMAGING OF BRAIN TUMORS IN A MEDULLOBLASTOMA MOUSE MODEL.; Neuro-oncology; (2018).

Three-dimensional in vitro cell culture models in drug discovery and drug repositioning; Frontiers in Pharmacology; (2018).

Beta-hairpin hydrogels as scaffolds for high-throughput drug discovery in three-dimensional cell culture; Analytical Biochemistry; (2017).

β-hairpin peptide hydrogels for package delivery; Advanced Drug Delivery Reviews; (2017).

Sustained release of active chemotherapeutics from injectable-solid β-hairpin peptide hydrogel; Biomaterials Science; (2016).

Transcriptional regulators of Na,K-ATPase subunits; Frontiers in Cell and Developmental Biology; (2015).

Epidermal growth factor signaling in transformed cells; International Review of Cell and Molecular Biology; (2015).

Peptide hydrogels - versatile matrices for 3D cell culture in cancer medicine; Frontiers in Oncology; (2015).

Na,K-ATPase β₁-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity; Molecular Cancer; (2015).

Cancer as a channelopathy: Ion channels and pumps in tumor development and progression; Frontiers in Cellular Neuroscience; (2015).

EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation; BMC Cell Biology; (2015).

Beta hairpin peptide hydrogels as an injectable solid vehicle for neurotrophic growth factor delivery; Biomacromolecules; (2015).

Crosstalk of oncogenic signaling pathways during epithelial-mesenchymal transition; Frontiers in Oncology; (2014).

Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma; Cancer Medicine; (2014).

Regulation of Na,K-ATPase β₁-subunit in TGF-β₂-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells; Experimental Eye Research; (2013).

Sonic Hedgehog-Induced Histone Deacetylase Activation Is Required for Cerebellar Granule Precursor Hyperplasia in Medulloblastoma; PLoS ONE; (2013).

Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer; American Journal of Physiology - Lung Cellular and Molecular Physiology; (2012).

Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis; BMC Cancer; (2012).

Na,K-ATPase β-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells; Journal of Cell Science; (2012).

Therapeutic potential of curcumin in gastrointestinal diseases.; World journal of gastrointestinal pathophysiology; (2011).

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo; BMC Cancer; (2011).

Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor; Experimental Cell Research; (2011).

Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles; Biomaterials; (2011).

Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis; Molecular Cancer Therapeutics; (2010).

The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation; Proceedings of the National Academy of Sciences of the United States of America; (2010).

Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase β₁-subunit; Journal of Molecular and Cellular Cardiology; (2009).

Na,K-ATPase and epithelial tight junctions; Frontiers in Bioscience; (2009).

α-Catenin overrides Src-dependent activation of β-catenin oncogenic signaling; Molecular Cancer Therapeutics; (2008).

Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability; Molecular Cancer Therapeutics; (2008).

Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability (Molecular Cancer Therapeutics (2008) 7, (2142-2151)); Molecular Cancer Therapeutics; (2008).

Na,K-Adenosine Triphosphatase α₁-Subunit Predicts Survival of Renal Clear Cell Carcinoma; Journal of Urology; (2008).

Evidence for a potential tumor suppressor role for the Na,K-ATPase beta1-subunit.; Histology and histopathology; (2008).

Evidence for a potential tumor suppressor role for the Na,K-ATPase ß₁-subunit; Histology and Histopathology; (2008).

Interactions of tight junctions with membrane channels and transporters; Biochimica et Biophysica Acta - Biomembranes; (2008).

Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells; American Journal of Physiology - Gastrointestinal and Liver Physiology; (2007).

Janus Model of The Na,K-ATPase β-Subunit Transmembrane Domain: Distinct Faces Mediate α/β Assembly and β-β Homo-oligomerization; Journal of Molecular Biology; (2007).

Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: Implications for targeting to tumor vasculature; Microvascular Research; (2006).

Estrogen receptor-α binds p53 tumor suppressor protein directly and represses its function; Journal of Biological Chemistry; (2006).

Identification of protein kinase C as an intermediate in NA, K-atpase beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells; Cellular and Molecular Biology; (2006).

Renal clear-cell carcinoma: An ultrastructural study on the junctional complexes; Histology and Histopathology; (2005).

Multiple functions of Na,K-ATPase in epithelial cells; Seminars in Nephrology; (2005).

N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: Implications for immunotherapy; Molecular Cancer Therapeutics; (2005).

Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility; Molecular Biology of the Cell; (2005).

HPAF-II, a cell culture model to study pancreatic epithelial cell structure and function; Pancreas; (2004).

Repression of Na,K-ATPase β₁-Subunit by the Transcription Factor Snail in Carcinoma; Molecular Biology of the Cell; (2004).

Na,K-ATPase β₁-subunit increases the translation efficiency of the α₁-subunit in MSV-MDCK cells; Molecular Biology of the Cell; (2004).

Role of Na-K-ATPase in the assembly of tight junctions; American Journal of Physiology - Renal Physiology; (2003).

Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity.; Cancer research; (2003).

A Novel Cytoplasmic Tail MXXXL Motif Mediates the Internalization of Prostate-specific Membrane Antigen; Molecular Biology of the Cell; (2003).

Expression of Na,K-ATPase β-subunit in transformed MDCK cells increases the translation of the Na,K-ATPase α-subunit; Annals of the New York Academy of Sciences; (2003).

Na,K-ATPase in the regulation of epithelial cell structure; Annals of the New York Academy of Sciences; (2003).

Na,K-ATPase inhibition alters tight junction structure and permeability in human retinal pigment epithelial cells; American Journal of Physiology - Cell Physiology; (2003).

Polarity of prostate specific membrane antigen, prostate stem cell antigen, and prostate specific antigen in prostate tissue and in a cultured epithelial cell line; Prostate; (2003).

Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity; Cancer Research; (2003).

Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells; Molecular Biology of the Cell; (2001).

Na,K-ATPase β-subunit is required for epithelial polarization, suppression of invasion, and cell motility; Molecular Biology of the Cell; (2001).

Reduced expression of β-subunit of NA,K-ATPase in human clear-cell renal cell carcinoma; Journal of Urology; (1999).

Highly specific separation of heterogeneous cell populations by lectin- coated beads: Application for the isolation of inner medullary collecting duct cells; Experimental Nephrology; (1998).

Only the first and the last hydrophobic segments in the COOH-terminal third of Na,K-ATPase α subunit initiate and halt, respectively, membrane translocation of the newly synthesized polypeptide: Implications for the membrane topology; Journal of Biological Chemistry; (1996).

A simple biochemical approach to quantitate rough endoplasmic reticulum; American Journal of Physiology - Cell Physiology; (1995).

Activation of Tsk and Btk tyrosine kinases by G protein βγ subunits; Proceedings of the National Academy of Sciences of the United States of America; (1995).