Sigrid Langhans, PhD

Radiotracers for Molecular Imaging of Angiotensin-Converting Enzyme 2; International Journal of Molecular Sciences; (2024).

PET Imaging of Neurofibromatosis Type 1 with a Fluorine-18 Labeled Tryptophan Radiotracer; Pharmaceuticals; (2024).

Abusive Head Trauma Animal Models: Focus on Biomarkers; International Journal of Molecular Sciences; (2023).

3D Hydrogel Cultures for High-Throughput Drug Discovery; Methods in molecular biology (Clifton, N.J.); (2023).

Advanced Neuroimaging Approaches to Pediatric Brain Tumors; Cancers; (2022).

Radiosynthesis of 1-(2-[¹⁸F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol; Journal of Visualized Experiments; (2021).

Unravelling neuroinflammation in abusive head trauma with radiotracer imaging; Pediatric Radiology; (2021).

In Vivo and Ex Vivo Pediatric Brain Tumor Models: An Overview; Frontiers in Oncology; (2021).

Using 3D in vitro cell culture models in anti-cancer drug discovery; Expert Opinion on Drug Discovery; (2021).

PET imaging of medulloblastoma with an 18F-labeled tryptophan analogue in a transgenic mouse model.; Scientific reports; (2020).

Implementation of a High-Throughput Pilot Screen in Peptide Hydrogel-Based Three-Dimensional Cell Cultures; SLAS Discovery; (2019).

Moving Myeloid Leukemia Drug Discovery Into the Third Dimension.; Frontiers in pediatrics; (2019).

A Functional Interaction Between Na,K-ATPase β2-Subunit/AMOG and NF2/Merlin Regulates Growth Factor Signaling in Cerebellar Granule Cells; Molecular Neurobiology; (2019).

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning.; Frontiers in pharmacology; (2018).

RADI-17. EVALUATION OF A NOVEL F-LABELED TRYPTOPHAN TRACER FOR PET IMAGING OF BRAIN TUMORS IN A MEDULLOBLASTOMA MOUSE MODEL.; Neuro-oncology; (2018).

β-hairpin peptide hydrogels for package delivery.; Advanced drug delivery reviews; (2017).

Beta-hairpin hydrogels as scaffolds for high-throughput drug discovery in three-dimensional cell culture.; Analytical biochemistry; (2017).

Sustained release of active chemotherapeutics from injectable-solid β-hairpin peptide hydrogel.; Biomaterials science; (2016).

Beta Hairpin Peptide Hydrogels as an Injectable Solid Vehicle for Neurotrophic Growth Factor Delivery.; Biomacromolecules; (2015).

EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation.; BMC cell biology; (2015).

Transcriptional regulators of Na,K-ATPase subunits.; Frontiers in cell and developmental biology; (2015).

Peptide Hydrogels - Versatile Matrices for 3D Cell Culture in Cancer Medicine.; Frontiers in oncology; (2015).

Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.; Molecular cancer; (2015).

Cancer as a channelopathy: ion channels and pumps in tumor development and progression.; Frontiers in cellular neuroscience; (2015).

Crosstalk of Oncogenic Signaling Pathways during Epithelial-Mesenchymal Transition.; Frontiers in oncology; (2014).

Epidermal growth factor signaling in transformed cells.; International review of cell and molecular biology; (2014).

Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma.; Cancer medicine; (2014).

Sonic hedgehog-induced histone deacetylase activation is required for cerebellar granule precursor hyperplasia in medulloblastoma.; PloS one; (2013).

Regulation of Na,K-ATPase β1-subunit in TGF-β2-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells.; Experimental eye research; (2013).

Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer.; American journal of physiology. Lung cellular and molecular physiology; (2012).

Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis.; BMC cancer; (2012).

Na,K-ATPase β-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells.; Journal of cell science; (2012).

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo.; BMC cancer; (2011).

Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles.; Biomaterials; (2011).

Therapeutic potential of curcumin in gastrointestinal diseases.; World journal of gastrointestinal pathophysiology; (2011).

Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor.; Experimental cell research; (2011).

Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis.; Molecular cancer therapeutics; (2010).

The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.; Proceedings of the National Academy of Sciences of the United States of America; (2010).

Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.; Journal of molecular and cellular cardiology; (2009).

Na,K-ATPase and epithelial tight junctions.; Frontiers in bioscience (Landmark edition); (2009).

Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability.; Molecular cancer therapeutics; (2008).

Evidence for a potential tumor suppressor role for the Na,K-ATPase beta1-subunit.; Histology and histopathology; (2008).

alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.; Molecular cancer therapeutics; (2008).

Interactions of tight junctions with membrane channels and transporters.; Biochimica et biophysica acta; (2007).

Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma.; The Journal of urology; (2007).

Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: implications for targeting to tumor vasculature.; Microvascular research; (2006).

Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function.; The Journal of biological chemistry; (2006).

Janus model of the Na,K-ATPase beta-subunit transmembrane domain: distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization.; Journal of molecular biology; (2006).

Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells.; American journal of physiology. Gastrointestinal and liver physiology; (2006).

Multiple functions of Na,K-ATPase in epithelial cells.; Seminars in nephrology; (2005).

N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: implications for immunotherapy.; Molecular cancer therapeutics; (2005).

HPAF-II, a cell culture model to study pancreatic epithelial cell structure and function.; Pancreas; (2004).

Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.; Molecular biology of the cell; (2004).

Na,K-ATPase beta1-subunit increases the translation efficiency of the alpha1-subunit in MSV-MDCK cells.; Molecular biology of the cell; (2004).

Repression of Na,K-ATPase beta1-subunit by the transcription factor snail in carcinoma.; Molecular biology of the cell; (2003).

A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen.; Molecular biology of the cell; (2003).

Role of Na-K-ATPase in the assembly of tight junctions.; American journal of physiology. Renal physiology; (2003).

Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity.; Cancer research; (2003).

Expression of Na,K-ATPase beta-subunit in transformed MDCK cells increases the translation of the Na,K-ATPase alpha-subunit.; Annals of the New York Academy of Sciences; (2003).

Na,K-ATPase in the regulation of epithelial cell structure.; Annals of the New York Academy of Sciences; (2003).

Polarity of prostate specific membrane antigen, prostate stem cell antigen, and prostate specific antigen in prostate tissue and in a cultured epithelial cell line.; The Prostate; (2003).

Na,K-ATPase inhibition alters tight junction structure and permeability in human retinal pigment epithelial cells.; American journal of physiology. Cell physiology; (2003).

Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells.; Molecular biology of the cell; (2001).

Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility.; Molecular biology of the cell; (2001).

Highly specific separation of heterogeneous cell populations by lectin-coated beads: application for the isolation of inner medullary collecting duct cells.; Experimental nephrology; (1998).