Scott L. Weiss, MD

Critical Care

Primary Office

Nemours Children's Hospital, Delaware Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803 Appointment: (800) 416-4441

Get to Know Me

Scott L. Weiss, MD MSCE FCCM is an associate professor of pediatrics at Thomas Jefferson University and division chief of critical care medicine at Nemours Children’s Hospital. Previously, Dr. Weiss was on the faculty at the Children’s Hospital of Philadelphia, where he earned recognition as an international expert in pediatric sepsis.  Dr. Weiss’ NIH-funded research focuses on epidemiology, fluid resuscitation and mitochondrial dysfunction in pediatric sepsis.

Why I Treat Children

Medicine offers a rare opportunity to engage with an individual at a vulnerable point of suffering from illness or injury, especially in critical care. I wear this as a badge of humility and respect for our patients and families. When the patient is a child, the trust offered by a family is particularly noteworthy and opportunity to support health and well-being is particularly impactful. I am also constantly amazed that, despite not feeling their best, children look to play, smile and enjoy life rather than seeing themselves as patients.  In the intensive care unit, I am inspired every day by the children and their families, which drives me to provide the best care possible.

What I'm Passionate About

My clinical focus is on children with sepsis, which is a medical emergency of life-threatening organ failure caused by a severe infection. I have been privileged to work with local, national and international teams to optimize systems and methods to recognize and treat sepsis in children to reduce negative impacts that this illness can have on families.

How I Try to Make A Difference

In addition to my clinical responsibilities in the pediatric ICU, I work as a scientist studying mechanisms of organ failure during sepsis. In particular, I focus on the role of mitochondria in sepsis. Mitochondria are the parts of our cells that produce the energy our body needs to stay healthy. My research seeks to understand how sepsis damages mitochondria, in order to develop new therapies that will promote recovery from sepsis-induced organ failure.

Education & Training

Fellowship

  • Pediatric Critical Care Med - McGaw Medical Center of Northwestern University, 2011

Internship Residency

  • General Pediatrics - Boston Childrens Hospital/Boston Medical Center, 2007

Medical/Dental School

  • MD - Harvard University, 2004

Board Certifications

  • American Board of Pediatrics/Pediatric Critical Care
  • American Board of Pediatrics/General Pediatrics

Awards & Recognition

  • 2022 Top Ten Reviewer, Pediatric Research
  • 2022 Presidential Citation, Society of Critical Care Medicine
  • 2021 Star Research Achievement Award, Society of Critical Care Medicine Annual Congress, Orlando, FL
  • 2021 Presidential Citation, Society of Critical Care Medicine
  • 2020 Star Research Achievement Award, Society of Critical Care Medicine Annual Congress, Orlando, FL
  • 2020 Presidential Citation, Society of Critical Care Medicine
  • 2019 Presidential Citation, Society of Critical Care Medicine
  • 2018 Pediatric Section Travel Grant Award, Society of Critical Care Medicine Annual Congress, San Antonio, TX
  • 2018 Presidential Citation, Society of Critical Care Medicine
  • 2017 Fellow of Critical Care Medicine (FCCM), Society of Critical Care Medicine
  • 2017 Editor’s commendation for authorship in Emergency Medicine, UpToDate
  • 2017 Presidential Citation, Society of Critical Care Medicine
  • 2017 Pediatric Section Travel Grant Award, Society of Critical Care Medicine Annual Congress, Honolulu, HI
  • 2017 Star Research Achievement Award, Society of Critical Care Medicine Annual Congress, Honolulu, HI
  • 2015 Patient-Oriented Research Track Award, CHOP Research Poster Day, Philadelphia, PA
  • 2014 Sepsis Specialty Research Award, Society of Critical Care Medicine Annual Congress, San Francisco, CA
  • 2010 Pediatric Critical Care Colloquium Research Award, Pittsburgh, PA

Insurance Accepted

  • Aetna Better Health PA Kids HMO
  • Aetna HMO
  • Aetna PPO/POS/EPO
  • Amerihealth Caritas Delaware
  • Carefirst MD Community Health Plan Mcaid
  • Cigna Lifesource Transplant
  • Cigna/Great West HMO EPO POS
  • Cigna/Great West PPO
  • Delaware First Health
  • Delaware Medicaid/Diamond State
  • Devon Health Services
  • Fidelis Care NJ Medicaid HMO
  • First Health/Affordable PPO
  • Geisinger Health Plan Commercial
  • Health Partners Medicaid/Kidz Partner HMO
  • Highmark Blue Cross Blue Shield of Delaware
  • Highmark Medicaid Health Options
  • Horizon Blue Cross Blue Shield of New Jersey
  • Independance Blue Cross/Amerihealth/Keystone Health Plan
  • Insurance Administrators of America
  • INTEGRA Administrative Group (ClaimsBridge)
  • Keystone First Medicaid HMO
  • Lifetrac Transplant
  • Maryland Medicaid
  • Multiplan PPO
  • National Transplant (Humana)
  • New Jersey Medicaid
  • Olympus Managed Healthcare PPO DE/PA
  • Pennsylvania Medicaid
  • Preferred Healthcare PPO
  • Private Health Care Systems (PHCS)
  • Qualcare HMO/POS/PPO
  • Star Healthcare Network
  • Three Rivers Provider Network
  • Tricare/Humana Military Health Services/CHAMPVA
  • United Healthcare of the Mid-Atlantic
  • UPMC MCAID/CHIP PA DE
  • US Family Health Plan
  • Wellpoint Maryland Medcaid

Research Activities

  • Mitochondrial Dysfunction in Pediatric Sepsis
  • Effect of Mitochondrial Quality Control on Systemic Inflammation and Organ Dysfunction in Pediatric Sepsis
  • PRagMatic Pediatric Trial of Balanced versus NOrmaL Saline FlUid in Sepsis (PRoMPT BOLUS international, multicenter randomized clinical trial)
  • Genotype Variation Underlying Pediatric Sepsis Sub-phenotypes
  • Readmissions After Pediatric Sepsis

Medical Interests

  • Sepsis
  • Multiple organ dysfunction syndrome (MODS)
  • Immunometabolism
  • Fluid resuscitation
  • Epidemiology & patient outcomes

  • English