Pediatric Research: Clinical Trials
Clinical Trials
At Nemours Children's, we’re actively seeking new approaches to the prevention, diagnosis and treatment of childhood diseases. Our goal, in everything we do, is to improve the lives of the children we see, as well as those of children everywhere.
This listing below contains information on clinical trials, clinical studies and registries underway at Nemours facilities in the Delaware Valley and Florida.
What is a clinical trial or study?
A clinical trial or clinical study is research that evaluates the use of a new intervention (such as a new drug, device, treatment or technique) on human subjects with a particular disease or condition.
What is a registry?
A registry is a research collection of medical information from people who have received or are receiving a certain intervention for a particular disease or condition. Often called “summary medical information,” these are the health records that patients have either provided — or have authorized researchers to access — in order to populate a registry. Researchers can then analyze registries to look for patterns in the data and evaluate whether better outcomes under certain conditions are consistently associated with a particular intervention. Participation in a registry is voluntary and confidential.

Are clinical trials right for your child?
Learn more about clinical trials and get answers to your questions.
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Delaware Valley/Greater Philadelphia
Clinical Trials Offered by Nemours Children's Health, Delaware
- A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis
- A Phase 2 Basket Study of Vosoritide in Children Wth Turner Syndrome, Short Stature Homeobox-Containing Gene Deficiency, and Noonan Syndrome With an Inadequate Response to Human Growth Hormone
- A Phase 3, 2 Arm-, Open-Label Study to Evaluate the Safety and Pharmacodynamics of Long-term Ivacaftor
- A Trial of Multimodality Therapy for Extra-Ocular Retinoblastoma
- ACHieve: A Multicenter, Longitudinal, Observational Study of Children With Achondroplasia
- Achondroplasia and Natural History
- Anomalous Aortic Origin of a Coronary Artery Registry
- Applied Genomics Clinical Trial in the Delaware Valley
- Atrioventricular Septal Defect Registry
- Auditory Function in Children With ADHD
- Brain Research at Nemours Children’s Hospital, Delaware
- Caspofungin vs. Fluconazole to Prevent Fungal Infections
- Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)
- Costello Syndrome: Clinical and Molecular Investigations
- CP Hip Outcomes Project (CHOP)
- Craniospinal Radiotherapy in Children With Medulloblastoma
- Cystic Fibrosis Foundation Patient Registry
- Dasatinib Added to Standard Chemotherapy in Pediatric Patients
- Dose Escalation of Metformin in Children With Solid Tumors
- Effect of LDL-Apheresis on Cardiovascular and Renal Outcomes in Focal Segmental Glomerulosclerosis
- Effect of TRPV4 Mutation on Calcium Channel Function
- Effects of Chemotherapy Drugs on High Risk Medulloblastoma
- Efficacy and Safety of Faster-Acting Insulin Aspart in Children With Type 1 Diabetes
- Efficacy and Safety of Tirzepatide Versus Placebo for the Treatment of Obesity and Weight-Related Comorbidities in Adolescents
- Evaluate the Effect of Low-Dose Oral Methotrexate in Pediatric Crohn's Disease With an Anti-TNF
- Evaluation of Rituximab Efficacy and Safety in Lymphoma
- Evaluation of the Safety of Daptomycin Vs. Standard of Care
- Experiences and Decision-Making for CFTR Modulators: A Qualitative Analysis
- Fluid Therapy and Cerebral Injury in Diabetic Ketoacidosis
- GALAXY: Generating Advancements in Longitudinal Analysis in X and Y Variations
- Improve Medication Adherence in Pediatric ALL
- Integrated Health Care and Community Care to Support Healthy Families
- Irinotecan Antibody in Children With Progressive Neuroblastoma
- Juvenile Pilocytic Astrocytomas & Optic Pathway Gliomas
- Key Adverse Events Following Childhood Cancer
- Left Ventricular Outflow Tract Obstruction Registry
- LIPOSORBER® HDE Post Approval Study
- Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children: MUSIC
- Measurement of Biometric Parameters Critical Care Practitioners
- Morquio A Registry Study (MARS)
- National Pediatric Cardiology Quality Improvement Collaborative
- National Wilms Tumor Late Effects Study
- Nemours Bariatric Surgery Registry
- Neuropsychological & Behavioral Outcomes in Children With Cancer
- Noninvasive Measurement of Pulmonary Dysfunction in Children With Cerebral Palsy
- Observational Study of the Incidence of Fibrosing Colonopathy
- Oral Insulin for Prevention of Diabetes in Relatives at Risk
- Osteogenesis Imperfecta (OI) and Spine Deformity
- Pediatric Heart Transplant Study (PHTS)
- Pediatric Peritoneal Dialysis Network Registry
- Perioperative Outcomes Multilevel Posterior Spinal Function
- Personalized Research on Diet-Ulcerative Colitis/Crohn's Disease
- Pharmacokinetics/Safety Profile of Digoxin in Infants With Single Ventricle Congenital Heart Disease
- PO Sorafenib in Recurrent Pediatric Solid Malignancies
- Postradiation Chemotherapy With Newly Diagnosed Ependymoma
- Primordial Registry at Nemours/Nemours Children’s Hospital, Delaware
- Prospective Multicenter Evaluation of a New Predictive Model for the Progression of AIS
- Prospective Study on Treatments of Legg-Calve-Perthes Disease
- Protocol for the Enrollment on the Official COG Registry
- Rhizomelic Chondrodysplasia Punctata Registry
- Role of Intestinal Microbiome and Bile acids in Pediatric NAFLD
- Safety and Efficacy of Pitolisant in Patients With Prader-Willi Syndrome
- SCFE — (SLIP) Registry — (Slipped Longitudinal International Prospective)
- Scoliosis and Surgical Instrumentation Comparison
- Scoliosis Outcomes Database Registry
- Spine and Pelvis Alignment in the Normal Growing Spine
- Stimulant Medication Effects on Hearing in Teenagers With ADHD
- Study of Scoliosis in Children with Cerebral Palsy
- Study of the Safety of Oxycodone Hydrochloride
- Synthetic Speech Quality Evaluation (HI Listeners)
- The Chest Wall and Spine Deformity Registry
- The EPIC Observational Study: Assessment of Pseudomonas
- The eXtraordinarY Babies Study: Baby Study for Children With XXX, XYY, XXY and Others
- The eXtraordinarY Babies Study: Natural History of Health in Children With Sex Chromosome Trisomy
- The Medial Olivocochlear Bundle and Speech-in-Noise Deficits
- The Trends, Outcome and Growth of Children With Renal Disease
- Treatment for Ewing Sarcoma Adding Topotecan to Chemotherapy
- Treatment of Progressive Early-Onset Spinal Deformities
- Trial of Modafinil to Improve Neurocognitive Deficits ACCL0922
- Tricuspid Atresia Registry
- Umbrella Long-Term Follow-Up Protocol
- Using Patient Data to Transform Care and Improve Outcomes for Children, Adolescents and Young Adults
Florida
Clinical Trials offered by Nemours Children's Health, Jacksonville
- A Phase 3 Study Assesing Subject Perception of Treatment Burden Using Weekly Versus Daily Injection
- Improving Medication Adherence With Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults With Asthma (MATCH)
- Neuropsychological & Behavioral Outcomes in Children With Cancer
- Personalized Research on Diet-Ulcerative Colitis/Crohn's Disease
- Using Patient Data to Transform Care and Improve Outcomes for Children, Adolescents and Young Adults
Clinical Trials offered by Nemours Children's Health, Orlando
- A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis
- Characterizing CFTR Modulated Changes in Sweat Chloride and Their Association With Clinical Outcomes
- Cystic Fibrosis Foundation Patient Registry
- Evaluate the Effect of Low-Dose Oral Methotrexate in Pediatric Crohn's Disease With an Anti-TNF
- Improving Medication Adherence With Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults With Asthma (MATCH)
- Inherited Neuropathies Consortium
- Key Adverse Events Following Childhood Cancer
- National Wilms Tumor Late Effects Study
- Neuropsychological & Behavioral Outcomes in Children With Cancer
- Protocol for the Enrollment on the Official COG Registry
- Study of Healthy Adaptation and Resilience to Pain in Emerging Adulthood (SHARPE)
- The Trends, Outcome and Growth of Children With Renal Disease
- Umbrella Long-Term Follow-Up Protocol
- Use of Human-Centered Design Methodology to Develop Nonimmerse Virtual Reality Asthma Education Program
- Using Patient Data to Transform Care and Improve Outcomes for Children, Adolescents and Young Adults
Clinical Trials offered by Nemours Children's Health, Pensacola
- A Phase 3 Study Assesing Subject Perception of Treatment Burden Using Weekly Versus Daily Injection
- Characterizing CFTR Modulated Changes in Sweat Chloride and Their Association With Clinical Outcomes
- Cystic Fibrosis Foundation Patient Registry
- Improving Medication Adherence With Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults With Asthma (MATCH)
Research Clinical Trials at Nemours
We’re actively seeking participants.
