Dose Escalation of Metformin With Standard Chemotherapy Drugs in Children With Solid Tumors

Clinical Trial

Offered by: Nemours Children's
Locations: Delaware Valley, Jacksonville, FL

Trial Name

A Phase I Trial of Dose Escalation of Metformin in Combination With Vincristine, Irinotecan and Temozolomide in Children With Relapsed or Refractory Solid Tumors 16962
View on Clinicaltrials.gov

What is the trial about?

To find the highest dose of Metformin that can be given safely in combination with standard chemotherapy drugs.

Who can participate?

Patients must be >1 year of age and ≤18 years of age at time of initiation of protocol therapy.

What is involved?

• Involvement will last for approximately 12 months. Patients will be seen in the clinic approximately 2 times a week while they are getting the treatments.
• Treatment on this study will consist of a combination of standard anti-cancer medications plus the study medication Metformin. The anti-cancer medications are vincristine, irinotecan and temozolomide (VIT).